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Intensity Theory and Test Verification

Liu Dabin,Han Wenba,Cai Bingqing and Han Xiaodong

Strategic Study of CAE 2007, Volume 9, Issue 12,   Pages 44-52

Abstract: A comparative study is developed between the test results of pulling or pressing in single directionIt is shown that the new balance particle intensity theory is more coincident with the test results than

Keywords： intensity theory     test results     yield     stress state    

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Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus(GDM): Results from a national survey on prevalence of GDM

Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 303-307 doi: 10.1007/s11684-010-0090-x

Abstract: The possibility of the 2 h oral glucose tolerance test (OGTT) as an alternative to the 3 h OGTT was investigatedretrieved from 4179 pregnant women who had OGTT performed after an abnormal 50 g glucose challenge testNo trend was shown where women with more risk factors were more likely to be overlooked if the 3rd h testcesarean section (CS), preterm births or macrosomia between the 79 cases and those with normal OGTT resultsOmission of the 3rd h glucose test in OGTT might be reasonable due to its convenience, better compliance

Keywords： diabetes     gestational     oral glucose tolerance test    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 903-912 doi: 10.1007/s11684-021-0871-4

Abstract: A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

Keywords： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 341-351 doi: 10.1007/s11709-017-0393-y

Abstract: study, 8 different types of joints are modelled and studied in the finite element program, and the resultsare verified by the experimental results which have been done in the laboratory.

Keywords： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (   

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Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Strategic Study of CAE 2011, Volume 13, Issue 8,   Pages 50-54

Abstract: companies, this paper expounds on the theoretical analysis and organizational methods of turning R & D resultsFaced with the widespread problem that putting R & D results into application is both lengthy andresponsibility and research institutes providing support," and explores the mode to promote R & D resultsThe problems in the ownership of research results, reward application and result ratification were analyzed

Keywords： R & D     major equipment     joint work of industry， college and research institute     transformation of results    

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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 470-474 doi: 10.1007/s11684-009-0077-7

Abstract: The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH ( < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% control group 34.83%; < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

Keywords： irinotecan     diarrhea     gentamycin     sodium bicarbonate     prevention    

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improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 67-70 doi: 10.1007/s11684-010-0023-8

Abstract: A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated intervention. At present, patients (=1395) from four communities have completed follow-up for one year, including the intervention group (=921) and usual care group (=474). The intervention programs included disease management by a care manager. Blood pressure of each patient was measured regularly. Compared with the control group, the net change of mean systolic blood pressure (SBP) was −6.75 (95% CI: −7.79 to −5.71, <0.001) mmHg, mean diastolic blood pressure (DBP) was −4.29 (95% CI: −5.08 to −3.49, <0.001) mmHg, and mean pulse pressure (PP) was −2.46 (95% CI: −3.50 to −1.43, <0.001) mmHg in the intervention group. The net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological treatment. The measures of integrated intervention for hypertension patients in communities can lower significantly not only SBP and DBP, but also PP. It is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.

Keywords： hypertension     community     pharmacological adherence     control of blood pressure    

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 101-107 doi: 10.1007/s11684-020-0752-2

Abstract: Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

Keywords： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Mechanical performance analysis and stiffness test of a new type of suspension bridge

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1160-1180 doi: 10.1007/s11709-021-0760-6

Abstract: A stiffness test was carried out on the new type of suspension bridge with a small span, and the resultsThe results showed that the new suspension bridge had a better performance than the conventional suspension

Keywords： new type of suspension bridge     stiffness test     mechanical performance     railway bridge     space truss    

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Mixed mode properties of CNT reinforced composites using Arcan test rig

Jacob MUTHU

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 397-404 doi: 10.1007/s11709-015-0321-y

Abstract: Composite materials reinforced with carbon nanotubes were mechanical tested using Arcan test rig underArcan test rig was designed and fabricated to work with the Shimadzu testing machine.The results show that the functionalised CNTs have improved the fracture behavior by acting as bridge

Keywords： CNT     composites     Arcan test rig     stress intensity factor    

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Accelerated life-time test of MEA durability under vehicle operating conditions in PEM fuel cell

Tian TIAN, Jianjun TANG, Wei GUO, Mu PAN

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 326-333 doi: 10.1007/s11708-017-0489-z

Abstract: In this paper, a novel accelerated test method was proposed to analyze the durability of MEA, consideringThe experimental results indicate that the proposed method can effectively destroy the MEA in a short

Keywords： polymer electrolyte membrane fuel cell     accelerated life-time test     load cycling test     durability    

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XB High Accuracy Rocket Sled Test Track

Yang Xingbang

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 98-104

Abstract:

Rocket sled test track is a large ground dynamic simulating test facility.China has successfully built the world ´s only track —XB high accuracy rocket sled test track

Keywords： rocket sled     test track     ground dynamic simulating test    

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Application of metal magnetic memory test in failure analysis and safety evaluation of vessels

Yiliang ZHANG, Song YANG, Xuedong XU

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 1,   Pages 40-48 doi: 10.1007/s11465-009-0003-3

Abstract: Metal magnetic memory test (MMMT), which is a new subject in the field of nondestructive examination,MMMT and other test methods are applied in the study to put a propylene purifier of a temperature-jumpResults are as follows: The margin of safety declines after the purifier is overburnt; several stressresidual stresses existing in the area of the base metal and weld zone are still greater than 0.5 , which results

Keywords： Metal magnetic memory test (MMMT)     nondestructive testing (NDT)     residual stress     propylene purifier     ammonia    

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Industrialization： Extricating Itself from Difficulty by System Building

Guo Lihong

Strategic Study of CAE 2002, Volume 4, Issue 1,   Pages 23-25

Abstract:

After the shortage economy by and large come to an end, the most serious shortage China faced in all fields is the shortage of systems. In order to accelerate the application of high and new technology in production and improve China´s economic competitiveness in international market, it is necessary to strengthen the economic restructuring, i.e.the system building.

Keywords： high and new technology     application of research results to production     economic restructuring    

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Title Author Date Type Operation

Intensity Theory and Test Verification

Liu Dabin,Han Wenba,Cai Bingqing and Han Xiaodong

Journal Article

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus(GDM): Results from a national survey on prevalence of GDM

Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG

Journal Article

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Journal Article

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Journal Article

Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Journal Article

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Journal Article

improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Journal Article

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Journal Article

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Journal Article

Mechanical performance analysis and stiffness test of a new type of suspension bridge

Journal Article

Mixed mode properties of CNT reinforced composites using Arcan test rig

Jacob MUTHU

Journal Article

Accelerated life-time test of MEA durability under vehicle operating conditions in PEM fuel cell

Tian TIAN, Jianjun TANG, Wei GUO, Mu PAN

Journal Article

XB High Accuracy Rocket Sled Test Track

Yang Xingbang

Journal Article

Application of metal magnetic memory test in failure analysis and safety evaluation of vessels

Yiliang ZHANG, Song YANG, Xuedong XU

Journal Article

Industrialization： Extricating Itself from Difficulty by System Building

Guo Lihong

Journal Article